Some of the cities, towns, and places in Lee County are Argyle, Cedar, Charleston, Croton, Denmark, Des Moines, Donnellson, Fort Madison, Franklin, Green Bay, Harrison, Houghton, Jackson, Jefferson, Keokuk, Madison, Marion, Montrose, Mooar, Mount Hamill, New Boston, Pilot Grove, Pleasant Ridge, Primrose, Sandusky, St. Paul, Van Buren, Viele, Vincennes, Washington, West Point, Wever

Lee County is the southernmost county in the U.S. state of Iowa. As of the 2020 census, the population was 33,555. The county seats are Fort Madison and Keokuk. Lee County is part of the Fort Madison–Keokuk, IA–IL–MO Micropolitan Statistical Area. It was established in 1836.